Started off his career as a writer and journalist while in college and by the time he has completed his physics degree and joined automobile engineering at MIT-Anna university, he was already an established writer. With no backing on film experience, Susi Ganesan assisted Mani Ratnam in movies like "Bombay", "Iruvar" and "Dil Se". In 2000 he directed his first film "virumbugiren" A love story in a village backdrop the film. The film got 4 Tamil Nadu state awards for best director, best film, best actress and best supporting actress. His next film "five star" was a film about love and friendship, the film brought a strong message that genuine friendship can exist between opposite sexes. The film was one of the big hits of 2002 and Susi Ganesan received the best screenplay writer award from the state government of Tamil Nadu in the same year. In 2006 his third film "Thiruttu Payale" a different kind of film based on crime/thriller genre with a romantic touch. The film received a number of accolades from the critics and was third biggest grosser in that year and was again one of the biggest hits of 2006 and it received the state award for best film, then in 2009 came "Kanthaswamy" the film was a big hit had a social message as it was based on black money and was the first southern film where the protagonist played a superhero character. The success in his films made him enter the Bollywood level. He made his Bollywood debut with his Hindi remake of "Thiruttu Payale". He named this film Shortcut Romeo and was released in 2013. After a break from the Tamil film industry, in 2017, Susi Ganeshan made a sequel to his sleeper hit film "Thiruttu Payale" and titled it "Thiruttu Payale II", starring Bobby Simha, Prassana, and Amala Paul in lead roles. He is now in talks for working on another Bollywood film.